01 - Set oven to 375°F (190°C) and allow it to reach temperature.
02 - Boil elbow macaroni in a large pot of salted water until al dente, approximately 8 minutes. Drain thoroughly.
03 - Melt 4 tablespoons unsalted butter in a large saucepan over medium heat. Whisk in 1/4 cup flour and cook for 2 minutes until bubbling. Gradually add 3 cups whole milk, whisking continuously. Simmer for 5 minutes until thickened.
04 - Stir in Dijon mustard, ground black pepper, and salt. Remove from heat. Add shredded cheddar, Gruyère, and 3/4 cup Parmesan cheese. Mix until completely blended and cheese is melted.
05 - Fold drained macaroni into cheese sauce, ensuring even coating.
06 - Pour mixture into a lightly greased 9x13-inch baking dish.
07 - Combine panko breadcrumbs and melted butter. Sprinkle evenly over macaroni. Top with remaining Parmesan cheese.
08 - Bake for 25 minutes until golden brown and bubbling. Cool for 10 minutes before serving.